This science mela is part of Khwarizmi Science Society’s National Science Movement 2016 and Beyond.
The cornea is the clear front of the eye and its clarity is important for the transmission of light to the retina for visual perception. The corneal surface is composed of an epithelium that is renewed by stem cells located at the periphery of the cornea, in a region known as the limbus. These so-called limbal stem cells can become deficient or dysfunctional as a result of many causes including chemical and thermal burns to the eye, hereditary causes such as Aniridia and Ectodermal Dysplasia, inflammatory diseases such as StevensJohnson Syndrome and Mucous Membrane Pemphigoid, and iatrogenic causes such as radiation therapy and topical chemotherapy. In the resulting disease of of Limbal Stem Cell Deficiency the corneal epithelium cannot be maintained resulting in chronic epithelial defects and the surface becomes replaced by the conjunctival epithelium and its blood vessels which surrounds the cornea and limbus resulting in visual loss. Limbal Stem Cell Deficiency is therefore a painful and blinding disease. It is difficult to manage at the best of times.
The complexity of biological system urgently demands computational models which can produce new understanding and new medicine. Keeping in view Khwarizmi Science society and Journal Club at IRCBM, COMSATS jointly presents a seminar on agent based modeling approach in Investigating Multiscale Tumorigenesis in the Warburg Effect.
Early stage tumorigenesis includes the formation of glycolytic cells in the tissue. However, the precise multi-scale processes underlying this transformation of healthy epithelial cells into tumorigenic glycolytic phenotypes, continues to be a matter of debate. In this work, we investigate this cellular transformation by using an agent based modeling approach and decode a multifactorial mechanism which upon triggering may lead to the onset of tumorigenesis