|Computer Models for the Differential Control of Gene Expression|
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We have developed computer models for the control of the activation of the calcium dependent transcription factors. Upon stimulation by foreign proteins, T-lymphocytes display spontaneous oscillation in calcium cellular concentration. Depending on the frequency of these oscillations, either one or more transcription factors are activated. The active transcription factors translocate to the nucleus and initiate gene expression. The model suggests a mechanism by which this differential gene expression occurs. This model faithfully reproduces a wide variety of experimental data. It also suggests key control points for these biochemical signalling pathways, which might suggest novel targets for immunosepressant drugs.
Prof. Dr. Saleet Jafri
School of Computational Sciences, George Mason University, USA
Dr. Waheed Akhtar
Director, Institute of Biochemistry and Biotechnology, University of the Punjab